Isaac Brown garnered 126 yards and two touchdowns on just six carries and Louisville amassed 543 yards of offense on Saturday and drubbed visiting Eastern Kentucky 51-17 in the season-opening game for both team.Louisville held its FCS guests to just 150 yards, including just 38 in the first half. Brown did his damage in less than a quarter-and-a-half. Last season’s ACC leader in rushing average scored on runs of 31 and 68 yards.Miller Moss played only in the first half and went 17-for-25 passing for 223 yards, a touchdown and two interceptions. The former Southern California starter spread his passes across to eight receivers, and he also added a rushing score in the victory.Caullin Lacy had a 93-yard punt return for a touchdown, which ranks as the second-longest in Louisville history. He also caught four of Moss’ passes for 62 yards.The Cardinals scored touchdowns on each of their first five drives and led 41-0 with 2:58 remaining in the first half after Keyjuan Brown’s 1-yard touchdown.Coach Jeff Brohm brought in second- and third-stringers to play in the second half. Brady Allen completed six of his nine throws for 69 yards with a touchdown and an interception.